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By Atomic structure

Compare between the atomic structures of Mercury and Gold.
Just take away one proton from Mercury's nucleus and you will get Gold!
Well, somehow you will have to get rid of 3 Neutrons also.:D

Also see the electronic orbits of Gold.
2, 8, 18, 32, 18 and 1
It's electrons are almost satiated, thats why it chemically reacts so scarcely. Just take away that extra electron and it will become completely Inert.

By Rasayana Alchemy

Rasayana is Indian alchemy, thousands of years old. The Yogis could do it in ancient times (as the legend goes). Some yogis until 100 years ago, could somehow digest Arsenic and mix it with their digestive juices (bile). Next they anointed copper in that juice and heat it for hours. When everything cooled, the copper would change to Gold!

The great Buddhist Philosopher Nagarjuna of India, invented 16 methods of gradually purifying Mercury. That involved several chemical reactions. Eventually Mercury would lose the affinity to react at all and its property would change. What is left behind, is a powder. That powder, when added to molten copper and heated for several days, yields Gold.

There is another method prevalent among the wise sages of the Himalayas (called, the Rasayaniks= chemists). They dip mercury for a whole year in a special mineral soln. The rest is the same as above. Actually these men are not in it for the Gold. Gold is a by-product to a medicinal substance that is supposed to extend Life... to many more years.

Western Alchemy

The western alchemists searched ardently for the Philosopher's stone. Their secrets were shrouded in the fog of myths. They gave each element a unique nickname and a symbolical expression. Even the intermediate compounds and alloys had secret identities! Below are 2 pictures depicting such symbols.