Hi guilty...
I have to say that you are brave or discussing your experience must be therapeutic for you. If I were in your shoes, I couldn't sleep peacefully nor would be doing my daily routine without thinking about the results. I won't judge you because you're not the first or last man to have sexual adventures. A lot of married or in relashionship people do the same, regardless of sexual orientations. And needless to say what some members here say about unprotected sex, it's never recommended. Now, at some point you'll have to choose one of the followings:
Tell her you have preference for ladyboys and including the truth about your encounters if possible and she decides whether to continue or terminate the relationship (you know better what is the convenience of this).
Continue your sexual encounters, don't say anything to her. For sooner or later she finds out, maybe from someone she knows or she sees you with a sex worker without you noticing it, or otherwise. It's not unusual to hire private investigators to prove infidelity.
You decide having sex ladyboys is your thing, and to be honest with yourself, you end your relationship. If later you met a GG you want to share your life with, you better start being honest with her (although it's not easy for them to accept that many men love that kind of sex).
Also if you really love her, you're being very inconsiderate, not just with you, also with her to have unprotected sex around, especially if she's ill. No one relieved of cancer will want to see an AIDS, herpes, crabs, syphilis, or many other more junk in the body. If so, then you're not good for her.
Good luck anyway