Oh fantasy, transgender, and identity.

Well, one problem might be that nobody has the slightest idea what you're talking about!

I'm guessing that you're trying to write stories set in some kind of fairly-realistic-but-fantasy world and want to know how TG characters would evolve? But I could be wrong...

PS. I've had a look at the links (I know all about 'Hard' SF so I knew what that scale meant) but as for Lego genetics, I think you'll find that men and women are pretty much identical genetically (embryos in the womb are basically female until hormones intervene) so that might not be an issue - you're not transplanting genetic material from two different species here.