Nobody can tell you how hormones will affect your penis. I know Tgirls who are on massive amounts of estrogen and testosterone blockers who can still get an erection, and I know some who never got erections even before hormones. It's often a psychological thing, though; most people who can't get it up don't really want to. Although if you're on testosterone blockers you will need to actually be turned on to get an erection; you probably won't get spontaneous ones or ... uhh ... morning wood anymore.
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Originally Posted by Bionca
If you want to retain functionality in the penis, hormone treatment will need to be very closely monitored. Going on and off high doses of estrogen can have some complications as the process of hormone replacement puts stress on the endocrine system (liver and kidneys in particular).
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That's very true. Even though my liver/kidneys and enzyme levels are fine, when I started estrogen I lost more hair than usual when I washed my hair for about four months, and my hair changed texture a bit.
There are a few blood tests you really should have done to make sure you're not at particularly high risk for blood clots. Some people can use cheaper oral estrogen, but for some it is a big risk.