This is a ridiculous movie that is kinda saved by good acting. I guess it's cute, and I can't really complain about anything that presents a transwoman as a human being, but it's absurd right from the beginning. Her therapist actually threatens to cancel her transition if she doesn't go see her son! And she dresses like a middle-aged crossdresser, not like any TS person I've met. And her son -- who is a gay prostitute -- both can't tell that she is TS, and then when he finds out he totally rejects her. Gay guys can read trannies pretty well, and they're usually pretty accepting about that sort of thing.
Sure, most movies are awfully contrived, but this goes pretty far beyond plausibility. It's almost like they're just trying to see how many edgy things they can cram in a movie. Her therapist blackmails her, she pretends she's a missionary and doesn't tell her son that she's really his father until he tries to fuck her. They get rolled by a hitchhiker. Her prostitute son blows a truck driver for money. And of course this male prostitute has such high standards that he tells her to fuck off when she admits who she is, but they both just happen to end up in LA because she wants to get her surgery done there (not Colorado, not Thailand), and he goes there to do gay porn. But when that falls through because he can't get it up on camera he decides to come crawling back to her -- and tries to sell her his porn.
I suppose it's entertaining, but I'd have to call Priscilla a more realistic look at TS life. Seriously, there are a lot of better TS-related movies out there:
Hedwig
Princesa
Wild Side
Normal
The Badge
Beautiful Boxer