Doctors I've talked to seem to agree that being on hormones generally render a TS girl sterile within just a few months, but the only way to be sure is to get her sperm count tested. Even if you have an extremely low sperm count, it is often still possible to have children at a fertility clinic by taking a testicular biopsy.
A lot of things can happen to your body when you start adding estrogen and blocking testosterone. Your testicles will start to atrophy. You have to understand what TS girls are doing to their bodies. They are not trying to mimic the hormones of a genetic woman; they are overloading their bodies to try and instigate female puberty, and they are trying to block all the testosterone possible. It is standard for TS girls to take 200mg/day of spiro, and this will quickly lower their testosterone level to much less than that of a genetic girl. I take a quarter that, and my testicles are pretty sore/sensitive most of the time. It's certainly not a good thing to do if you ever want to impregnate someone.
That said, you could just find one of those girls who does porn and has a boob job but isn't even on hormones.
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