Ketamine and Tiletamine are both veterinary anesthetics, though the former is also approved for human use, particularly among burn victims. I'm not sure why its anesthesia is preferable in this class of patient. They are typically used as a liquid for injection, but among the using class, the vials can be emptied, the liquid evaporated, and the precipitate insulfated. Alternatively, you can sometimes score a vial prior to dilution, in which case you don't have to go through the pains of evaporation. And in even another alternative, if you are not phobic of needles and injectable drugs, you can always inject the solution.
Ketamine's biggest claim to fame was use by Jim Lily, a 1960's scientist who injected a lot of ketamine and also dappled with sensory deprivation. He supposedly developed these elaborate theories regarding dolphin communication under the influence-- to be honest, I don't know if his ideas hold up under modern scrutiny, but he was quite the pioneer, if a bit eccentric.
To be honest, neither of these drugs do I have a huge impression of. Ketamine intoxification has a stage called the "K-Hole." This represents that dividing line between being somewhat messed up and being completely dissociated from one's self. Personally, I find it peaceful and enjoyable. Some have freaked out...For a pop culture reference, Marilyn Manson penned a song titled "Dissociative" on his album "Mechanical Animals." My take is that he pretty much freaked out, assuming the song was inspired by ketamine, as he claims. The lyrics go, "I can never get out of here...I don't want to explode in fear...Dead astronaut in space..." While those sentiments do capture the feeling to some extent, they really represent the panic side of the spectrum. Again, this is not atypical, I guess I'm just more at peace leaving my body behind.
Tiletamine is registered ONLY for veterinary use, but those of us creative enough to see the structural similarities among drugs, and brave enough to venture where few have gone before, have sampled this substance. The trademark name is technically a combination of a dissociative and a benzodiazepine. This benzodiazepine is what scares me, because I don't have tons of experience with them, and they can, in the wrong combination, be fatal if taken to excess. Thus my dapplings with tiletamine were always done with caution. Anecdoctal reports that I have read suggest that IV use of this drug can be VERY powerful, moreso than ketamine, but I was much too paranoid to venture into this realm blindly.
I must say, it seems I am a Tiletamine hard-head of sorts. I could cut several lines of the stuff and feel pretty good. I would go into a numb, relaxed state and would usually drift off to sleep eventually. I sampled a few vials over the years and shared with some friends...EVERY friend who ever tried it with me had a MUCH more severe reaction than me. All participants insulfated a line or took the equivalent of a small oral dose. The few that tried it with me almost invariably got INCREDIBLY messed up. Many ended up completely stupid, muttering jibberish, tripping over themselves, etc. In all cases, I had to remind the people what we had done the night before and tell them that yes, they had taken some drugs, and yes, they had gotten really messed up. One guy ended up staying with me in a hotel miles away from where he started because there was no way he was going to make it home. I don't think he had any recollection of getting there, no recollection of throwing up in my car, etc. It's odd the physiological differences between us...Why two overweight men should react so much more profoundly than me, maybe it speaks to my own junkie disposition. At the minimum, it should suggest EXTREME caution if ever trying a substance, you never know how your body will react...Not necessarily how your friend's body reacts.
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