Well, one problem might be that nobody has the slightest idea what you're talking about!

I'm guessing that you're trying to write stories set in some kind of fairly-realistic-but-fantasy world and want to know how TG characters would evolve? But I could be wrong...

PS. I've had a look at the links (I know all about 'Hard' SF so I knew what that scale meant) but as for Lego genetics, I think you'll find that men and women are pretty much identical genetically (embryos in the womb are basically female until hormones intervene) so that might not be an issue - you're not transplanting genetic material from two different species here.