Most gals are started on 2mg of Estradiol & 100mg of spironolactone as a T-Blocker. After a month you're upped to 4mg of estradiol. If you're a smoker or at high risk for an embolism, you'll go with a single 0.1mg patch weekly for a month and switched over to two patches at a time after the first month.
I have dehydration issues with 100mg of spironolactone, so I take 50mg of spironolactone and suppliment it with 1mg of Finasteride.
Completely optional and debated, but I also take 100mg of progesterone in capsule form nightly for more natural, rounded breasts.
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