Whenever we feel an emotion, a particular liquid is secreted from the brain into the bloodstream and we have a particular sensation all over the body. According to the emotion and it's intensity, it can feel good, bad, exhilarating, irritating or even death may come.
So, everything is already in the brain, chemicals only stimulate one particular juice from the brain. But there is more to it than just the brain and nervous system. Spiritually speaking, the hallucinogen temporarily and forcibly separates the consciousness or soul from the grasp of the physical body. Like in a dream, temporarily the faculty of reason is put to rest.
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