GRH, absolutely - the terms "ladyboy" and "shemale" should be used with caution. I rarely use them - instead I prefer transsexual or transgendered or ts or tg. However, in Asia, where I live, the terms are not considered quite as antagonizing as in the West. Here trans woman will happily refer to themselves as ladyboys or shemales.
So again it's a matter of feeling you way in and use the right lingo for the occasion :-)
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