The Five Sexes: Biological Fact? Dr. Anne Fausto-Sterling is sure of it
 

Well known Biologist, Author and Professor Anne Fausto-Sterling from Brown University says there are at least 5 and probably more Biological sexes among humans and discusses them in in this article and she's also written a book. Attached is link to the article read and make a comment if you like. http://capone.mtsu.edu/phollowa/5sexes.html

thx it is very important topic
But I have a question
Is it possible that man/shemale menstruated regularly
and how we can know

Variety is the spice of life.

Well, it depends on what you call "menstruated". If it's the blood loss part, I don't recall knowing about any case it would have happened. But if you are talking about a cycle men and M2F tgirls would go through, it has already been proven. At least for men.

It's all about hormones. We all have hormonal cycles of different periods (ultradian, circadian and infradian). Everyone has an infradian hormonal cycle during about a month or so. Bearer of the XX chromosome pair have one during about 28 days, ending by the menstruations, and very often a little breakdown in spirit. Bearer of the XY chromosome pair also have that cycle but its duration is shorter, about 23 days.

As it is due to hormonal cycles and production, I don't know what the effect hormones M2F tgirls take would be on that cycle. It probably is disturbed, but how ?